Online Pre-Column Derivatization with Chromatographic Separation to Determine Folic Acid
نویسندگان
چکیده
منابع مشابه
Online pre-column derivatization with chromatographic separation to determine folic acid.
A simple, sensitive, and selective online pre-column derivatization high-performance liquid chromatographic method was developed and validated for the first time to determine trace levels of folic acid (FA). An oxidant cerium (IV) trihydroxyhydroperoxide packed reactor was used for pre-column oxidation and was combined by column switching with a C18 analytical column for sample enrichment and s...
متن کاملA Sensitive Liquid Chromatographic Method for the Analysis of Clarithromycin with Pre-Column Derivatization: Application to a Bioequivalence Study
Objective(s) A sensitive liquid chromatographic method for the analysis of clarithromycin- a macrolide antibiotic- in human serum, using pre-column derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl) is described. Materials and Methods The method involved liquid-liquid extraction of the drug and an internal standard (amantadine) followed by pre-column derivatization of the analytes...
متن کاملa sensitive liquid chromatographic method for the analysis of clarithromycin with pre-column derivatization: application to a bioequivalence study
objective(s) a sensitive liquid chromatographic method for the analysis of clarithromycin- a macrolide antibiotic- in human serum, using pre-column derivatization with 9-fluorenylmethyl chloroformate (fmoc-cl) is described. materials and methods the method involved liquid-liquid extraction of the drug and an internal standard (amantadine) followed by pre-column derivatization of the analytes wi...
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Objective(s) A sensitive liquid chromatographic method for the analysis of clarithromycina macrolide antibioticin human serum, using pre-column derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl) is described. Materials and Methods The method involved liquid–liquid extraction of the drug and an internal standard (amantadine) followed by pre-column derivatization of the analytes with F...
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Although chemical modification of analytes is a well-accepted adjunct to chromatography, little attention had been paid to the automation of pre-column derivatization techniques. An automated pre-column system would offer advantages when analyses are performed using labile derivatives; and also when the time between injections is long and so staff time spent on achieving maximum analytical outp...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2012
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/bms170